基本信息

姓名：王刚

职称：副教授

电话：13554497068

邮箱：[email protected]

教育背景

2013-10 至 2015-09, 广东工业大学, 药物化学, 博士后 （药物合成）

2008-09 至 2013-09, 浙江大学, 有机化学, 博士 （有机合成方法学）

2001-09 至 2005-07, 湖北大学, 应用化学, 学士

科研方向

1. 有机小分子催化的合成方法学

2. 杂环化合物的合成方法学

3. 药物合成工艺开发

4. 药物中间体及API合成

学术成果

发表论文：

(1) Chenbo Guo⁺, Yi Li⁺, Qiqi Zhang, Wanyu Yan, Jing Zou, Gang Wang*, Zhao-Lin He*. Base-promoted Annulations of α-Halohydroxamates with 2-(Substituted(tosyl)methyl)phenols for the Synthesis of 1,4-Benzoxazepine Derivatives. Tetrahedron 2025, 134777.

(2) Wanyu Yan, Qian Hong, Yi Li, Jing Zou, Gang Wang*, Zhao-Lin He*. Spiroannulations of β-Ketothioamides with Bromoenals via Selective C-Michael Addition and S-Michael Addition-Triggered Cascade Reactions. J. Org. Chem. 2024, 89, 14908–14918.

(3) Yi Li; Weinan Xu; Xidan Lei; Jiangbo Xi; Jing Zou; Gang Wang*; Zhao-Lin He*. Base-Mediated Tandem [3+2] Cycloaddition/Ring Openning Reaction of Arylhydrazonoyl Chlorides with Arylnitroso Compounds for Synthesis of Substituted Diazene Oxides. J. Org. Chem. 2023, 88, 14200–14204.

(4) Zhao-Lin He*; Wen Tian; Gang Wang*. Oxidative (3+3) Cycloaddition/Ring-Opening Reactions of Simple Urea Derivatives and N,N′-Cyclic Azomethine Imines to Construct 1,2,3,5-Tetrazine-4(1H)-one Derivatives. J. Org. Chem. 2023, 88, 8609–8618 .

(5) Gang Wang*; Jiang Wu; Yi Li; Zicheng Huang; Jing Zou; Zhao-Lin He*; Diastereoselective Synthesis of Pyrazolo[1,2-a][1,2,4]triazine Derivatives via Cross-1,3-dipolar Cyclizations of Azaoxyallyl Cations with N,N’-Cyclic Azomethine Imines. Eur. J. Org. Chem. 2023, 26, e202300450.

(6) Cheng Hang; Yan Ding-Ce; Wang Gang*; He Zhao-Lin*. [4+2] Cycloaddition reactions with azao-QMs of fulvenes: Construction of tetrahydroquinoline derivatives. Synlett 2022, 33, 795–799.

(7) Wang, Gang; Wu, Jiang; Cheng, Hang; Zhong, Cheng*; He, Zhao-Lin*. N-Heterocyclic Carbene Catalyzed [3+2] Annulations of β-Halocycloenals with Isatins and Mechanism Study, Eur. J. Org. Chem. 2021, 983–989.

授权发明专利 :

(1) 王刚，吴将，程行，何照林，袁相富，奚江波. 一种螺环氧化吲哚-环戊烷并丁烯酸内酯化合物的合成方法. 2019, 中国， 专利号：ZL201911015801.4

(2) 王刚，何照林，陈一，倪明旺，郑家练. 一种4-烷氧基-2-芳基巯基吗啉-3,5-二酮类化合物及制备方法. 2019, 中国，专利号：ZL201910131054.2

(3) 王刚，何照林，陈一，胡乾坤，李朝顺. 一种2H-1,4-噻嗪-3(4H)-酮类化合物及制备方法. 2018, 中国，专利号：ZL201810616552.3.

(4) 董长治，王刚，黄江，王荣，全霖阳. 一种含三氮唑基他克林-香豆素衍生物及其制备方法和用途. 2015, 中国，专利号：ZL201510880694.7.

招生要求

本科化学、应用化学、化工、制药等专业背景，报考有机化学专业